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The healthy low carb vs low fat study

Executive summary
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Many thanks to Annemarie Hogenbirk, who is a registered clinical nutritionist in NZ, for this week’s note. Annemarie spotted a study from the Harvard epidemiology production line within a few hours of it being published (on 21st January 2020). It was called “Association of low-carbohydrate and low-fat diets with mortality among US adults” (Ref 1).

At first sight it looked like one of Harvard’s standard outputs – an association reported between a food intake (low carb and low fat in this case) and a condition (mortality) having studied unreliable food frequency questionnaires in large US populations. Upon further examination, the paper was by no means standard and was quite surprising in parts. I’ve exchanged emails with the corresponding author and will share key points.

The study

The study used data from the US National Health and Nutrition Examination Survey from 1999 to 2014 for 37,233 adults, who were 20 years or older and for whom 24-hour dietary recall data were available.

The main outcome of interest was all-cause mortality, which was a good start. All-cause mortality is the ultimate measure that matters. Mortality is more important than events and all-cause mortality ensures that we don’t report fewer deaths from one condition, while missing more deaths from another condition.

In this note, I'm going to round as many numbers as possible to the nearest whole number – just to make it easier to read. The 37,233 adults had an average (mean) age of 50. The participants were split 53% female, 47% male. There were 297,768 years of follow-up. That's an average of 8 years follow-up. During this time there were 4,866 total deaths.


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