168 Responses to “How statin drugs really lower cholesterol & kill you one cell at a time”

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  1. avatar tarek says:

    i have take only one tablet of statin product and i get a terrible side effect in muscles

    • avatar Kath says:

      I took Crestor 10mg for 3 days and got severe leg muscle cramps so stopped, thankfully. The doctor put it down as a ‘reaction’, I suppose she didn’t want to add to the long list of statin ‘side effects’. I have since found out that people have died from irreversible muscle disintegration.

  2. avatar PB says:

    “This is classic modern poly pharmacy – having people on multiple medications. You take one drug, which has a side effect, so they give you another drug to overcome the side effect produced by the first.”
    This is what happened to me – well I’m pretty sure it all started with statins. I’ve been on Rosuvastatin for years, but didn’t really suffer any immediate side effects. After some time I started to suffer from insomnia, became depressed due to lack of sleep, so was prescribed anti-depressants and sleeping pills and now I’m hooked on them. I’m going to try and get myself off all these crappy meds starting with Rosuvastatin. I felt fine before being put on statins.

  3. avatar PB says:

    Hi Paul – the problem is that your doctor more than likely hasn’t a clue how statins work – he simply looks at your blood test results and prescribes what he’s been taught to. Probably protecting himself from a lawsuit too. My daughter is a doctor and hasn’t a clue either. She had been taught at medical school that high cholesterol is bad and statins are good. Ask him to explain how the mevalonate pathway works to see if he actually knows anything. Some doctors aren’t as intelligent as you might expect.

  4. avatar PB says:

    “The patient leaflet for rosastatin says…” I take it that you (Zoë and “Professor” Agarwal) mean Rosuvastatin?

    • avatar Zoë Harcombe says:

      Yes! Thankyou – sorted :-)

      • avatar Luz says:

        My cholesterol has been as high as 400 at times. The doctors for years have put me on statins, though I have had severe cramping. One of them told me to start taking CoQ10 and a little Tonic water. These do help.

        I am on Zetia and Livalo right now…

        What can I do? Help please…

        • avatar Zoë Harcombe says:

          Hi Luz – I can’t help with what you should do. I’m not a doctor. I don’t know anything about you – age, gender etc.

          I can share something interesting with you – which you may in turn want to talk to your doctor about – neither drug that you are taking has been shown to have any impact on heart disease…

          Zetia – opening paragraph: “ZETIA has not been shown to prevent heart disease or heart attacks” http://www.zetia.com/ezetimibe/zetia/consumer/cholesterol-medicine/index.jsp

          Livalo – see p17 of this http://www.consumerreports.org/health/resources/pdf/best-buy-drugs/StatinsUpdate-FINAL.pdf
          “Fluvastatin (Lescol and Lescol XL) and pitavastatin (Livalo) have not been shown to prevent heart attacks and strokes. So we can’t recommend either one.”

          So – you are taking two substances that will reduce your cholesterol (by impairing the body from making what it is designed to make) when these are known to have NO impact on heart disease. So you are getting no ‘benefit’ and you are getting costs – cramping and possibly other side effects: muscle aches; memory impairment; reduced cognitive ability; fatigue; loss of interest in sex – any of those ring any bells?

          I know what I would do but then I would never ever take a substance that would impair my body’s ability to do what it is designed to do – make cholesterol.

          Good luck with your research/discussions and any decisions that you may make
          Best wishes – Zoe

  5. avatar Willb says:

    I currently take simvastatin 20 mg nightly. I had a triple bypass 2yrs ago. My LDL is now too low ie 55 my HDL is just creeping up to 39. Surely it would make sense to reduce the statin to 10mg nightly given the fact that my LDL is so low. Your comments would be appreciated

  6. avatar Pauline says:

    Hi.. I was just told to start taking Lipitor by my doctor after my blood test showed a major increase in my total level 303, LDH at 211, and HDL at 55. Three months ago, she increased my Effexor to 215mg per day from 75mg per day. I have researched this and found that Effexor can drastically raise levels. Help?

    • avatar Zoë Harcombe says:

      Hi Pauline – apologies for the tardy reply. We’re on holiday and have just managed to find the brain cells to get on line :-)
      Many thanks for this – you’ve taught me something. I hadn’t heard of Effexor or was aware of the cholesterol impact. I’ve found the patient leaflet and done some surfing, as you have, and you’re quite right – the official Effexor patient leaflet lists increased cholesterol as a common side effect (1 in 10 people affected).

      This is classic modern poly pharmacy – having people on multiple medications. You take one drug, which has a side effect, so they give you another drug to overcome the side effect produced by the first. Given the blog topic that you posted on – where does this end – when you get cancer drugs because statins have destroyed your cells?! Effexor seems a pretty scary drug – are you really sure that you need to be on this and at this dose? With my main interest being weight, I couldn’t help but notice that Effexor, as with most similar drugs, has weight gain listed as a common side effect. That would make most of the people I know reject it straight away! If you have to take E, try lower dose and I then personally wouldn’t take another medication to deal with a consequence of the first. There’s no harm in a cholesterol level of 303 – especially given that you know why it has risen. I wouldn’t get into the spiral of multiple tablets that the pharma industry just loves. Does your doc know that Lipitor and Effexor are even safe together? I would bet that the two have never been studied together in a clinical trial.

      I hope this helps and many thanks for my learnings
      Very best wishes – Zoe

  7. avatar Prof. Venkatarama Krishnan says:

    I came across this website while searching for the effects of statins. I have disturbances in the EKG but my lipid profile was always well within the normal limits with LDL 100 and HDL 40. The first cardiologist talked me into taking Atorovastatin 10 mg a day and after taking it for a month, my thinking process was getting badly disturbed and I developed a little weakness in the limbs. I stopped taking it and after two weeks the symptoms disappeared. When I reported this to the doctor he did not think that the symptoms a were due to the statin. I went to a second cardiologist and he said that this is a placebo effect and asked me to take Crestor. I started taking 5mg every other day and after a month my feet started swelling. I stopped it and the swelling went away. The second doctor still insisted that these symptoms are placebo effects. I read through your blog and I am convinced that the statin does not agree with me. I will be interested in any take you may have on this situation.

    • avatar Zoë Harcombe says:

      Hi Prof. Krishnan – I’m a member of thincs (http://www.thincs.org/) – the growing group of scientists, researchers, academics and doctors who think that the cholesterol myth will go down in history as one of the greatest crimes committed against mankind. You’ve had the first hand experience. You’ve had the standard doctor dismissal of your experiences (of this, you are far from alone). I would recommend reading as much as you can on the topic and deciding your view on cholesterol and statins.

      If you put the word “cholesterol” in on the search box on my site, you’ll get lots of articles (http://www.zoeharcombe.com/index.php?s=cholesterol)
      Anything on here: http://drmalcolmkendrick.org/
      Or here: http://www.drbriffa.com/

      Books highly recommended are: Dr Duane Graveline – The Statin Damage Crisis or Lipitor: Thief of Memory.
      Dr Malcolm Kendrick – The Great Cholesterol Con
      Uffe Ravnskov – Fat & Cholesterol are good for you or Ignore the Awkward
      Jonny Bowden, Jimmy Moore – there are many books on these topics when you start to question the drug industry line.

      Good luck!
      Very best wishes – Zoe

      • avatar Bill P says:

        No one should take statins, I have been prescribed them simvastatin, atorvastatin, rosuvastatin and all made me really ill feeling sick, muscle pains all the time. Simvasatatin caused so much muscle wastage in my back I had to have physiotherapy for a whole year to try and build it all back up. We are all brainwashed by doctors who themselves are brainwashed to prescribe statins. My father-in law is in his eighties and was prescribed a statin then he wondered why he felt so sick all the time and he had constant pain in his legs, why on earth would any reasonable doctor prescribe someone of his age a drug like that that made him so unwell!

  8. avatar Mike Lock says:

    Surely this explanation could have been put in a more shorter form.

  9. avatar Mie says:

    Does that mean in the entire blog? I posted a couple of comments within a short period of time, yes, but under different blog posts.

  10. avatar Mie says:

    Taking your time with moderation when it comes to my comments, I see? :-)

    • avatar Andy says:

      Hi Mie,
      your comments were trapped by the spam filter. Probably as a result of the number of comments you posted in a short period of time.

  11. avatar Mie says:

    “The Framingham quotation I’ve most often seen is about fat and cholesterol:”

    … and deals with the unadjusted observations. When adjusted for confounding factors, the consumption of safa wasn’t beneficial in terms of TC or LDL levels.

  12. avatar Professor R.A. Agarwal says:

    I had coronary bypass operation in december 2013. ever since then iave been taking rosastatin 10mg. everyday. bleeding from the small intestine which took the hemoglobin down to 4-6 g/percent. had to be given blood transfusion every time. although anticoagulants have stopped the bleeding still took place. Could this be due to statins? what will happen if I stop statins? any answers?

    • avatar Zoë says:

      Hi Prof Agarwal – you need to take medical advice, as I’m sure you realise. The patient leaflet for rosuvastatin says to contact your doctor immediately if you develop any unusual bleeding. So, yes, this could be due to statins and it could stop if you stop taking statins – as could all the other horrors described in this blog post.

      I hope you find a doc who is open to the idea that statins are anything other than wonderful!
      Very best wishes – Zoe

  13. avatar Mark says:

    Paul, If you think your dcotor or cardio is impartial try asking him or her some basic questions about diet and heart health and see how little they know. I have so far askd 3 doctors and 2 cardios there opinion on the new Swedish dietary guidelines. Given how radical they are I would expect some sort of opinion. Not one of them new what I was talking about. When I gave one doctor the overview he proudly stated that he was a doctor not a nutritionist !. I tried to get him to realise that the two were the same if not closely related but gave up.

  14. avatar Mark says:

    I dont disagree with anything written here, I have being weaning my Mother off statins fro the last 6 months. She was put on a max dose for no good reason. You can see how we all get enamoured by the easy to check numbers however and the Framlingham study data that states no one with a total cholesterol below 3.9 and LDL below 3.0 had ever died of a heart attack within this very large study. If this is the case what are we to make of keeping LDL down. Should we pursue it but by more natural means. I have personally had lowered blood numbers by using Krill oil. Would value your opinion.

    • avatar Zoë says:

      Hi Mark – please do you have a reference for this bit? “no one with a total cholesterol below 3.9 and LDL below 3.0 had ever died of a heart attack within this very large study”. The Framingham quotation I’ve most often seen is about fat and cholesterol:

      “In Framingham, (Massachusetts), the more saturated fat one ate, the more cholesterol one ate, the more calories one ate, the lower the person’s serum cholesterol.” (original emphasis). (William Castelli, Archives of Internal Medicine, (July 1992), 152:7:1371-1372.) Castelli being the study director

      Many thanks – Zoe

  15. avatar Mie says:

    This entire blog post was amusing, but I have to give special credit to your “explanation” of FH. You do not mention the fact that abnormally high levels of circulating LDL are a major causative risk factor for atherosclerosis but pretend this is somehow totally different from what you state to be the main problem of FH patients – cells not being able to take in the LDL-cholesterol due to decreased LDL-receptor activity (which, of course, leads to abnormally high levels of circulating LDL)??

    Congrats. This level is rarely reached, even in cholesterol denialist circles.

    BTW, people with homozygous FH do receive at least some benefits from aggressive statin therapy but of course not the same kind as people with heterozygous FH. And these people do not die because their cells don’t get the cholesterol needed: they die due to premature atherosclerosis leading (mostly) to premature CAD.

  16. avatar Paul says:

    I came on this page as I was searching statins after accidentally taking my statin a second time instead of an anti heartburn drug this morning and was worried as it’s an overdose within 12 hours from correct statin dose.

    However I did read the article and it’s obviously made me VERY concerned about using statins at all.

    My point is this Zoe, nobody should alter their medication without prior expert medical consultation with a REAL LIFE doctor familiar with their case hands on. My previous doctor, a very experienced gentleman, told me specifically DO NOT MAKE CHANGES OR PANIC AFTER READING SCARE STORIES on the internet. (Like this page!)
    Zoe you SELL BOOKS do you not? Is this why you advise certain books, to make money? It’s worrying as you are NOT impartial, you have financial motive! Give away the information and we can take you as impartial, whist a financial driven motive to sell heath books credibiliy is much reduced. Just like the online financial services gurus and ‘take these 4 steps to health’ shysters, the final twist is PAY ME to save you!

    I’m going to bring this up with my new doctor, but as mentioned SEEK MEDICAL ADVICE before following ANY book or article where your own condition is unknown to the writer making blanket statements, even backed with data. You were NOT included in the data gathering!


    • avatar Zoë says:

      Hi Paul – it should make you concerned. I doubt your doctor has ever heard of the things that the Yosephs have uncovered. I’m encouraging people to read their book – not mine. I have not written any books about statins, so there’s no conflict. I just think that my fellow humans should know what statins actually do to the human body.

      As for giving books away for free – we give a lot away but we do need to sell some or we would starve to death! I don’t know what your job is but why don’t you do it for free? It continually baffles me that people think that authors should do their job for free but all other jobs should get paid?!

      Seek medical advice by all means but the point of the statins/cholesterol hypothesis is that the conflict is enormous and runs deep. The conflict is not the Yosephs possibly making 70 cents per copy (not many people know royalty rates) but Lipitor, one statin alone, having made $125 BILLION for Pfizer. Your doc could deliberately or unwittingly be part of this huge crime- as per the conflicts of those setting cholesterol targets uncovered by the Yosephs. This blog post (kindly providing a summary of the book for free) is merely presenting the facts about what statins actually do in the human body. You need to read a lot, take charge of your own health, listen to your doc, ask him/her a lot of questions – don’t just take statins because you trust white coats. That’s the bottom line!

      Best wishes – Zoe

    • avatar Mike Rohrbeck says:

      Zoe, I’m a convert after giving up statins and reversing my weight gain, lethargy, sleep problems, issues of mental clarity etc. The book Grain Brain is another to recommend that recaps so much of this science, which is at it’s core simple — cholesterol and most fats are good for you; grains and processed foods are inflammatory and bad over short and long term. Woe to Paul and most of us advised by doctors who believe the lies they’ve been told for decades about the presumed and false causal relationship between fat, cholesterol and heart disease. Good luck Paul and everyone about getting your doctor to say what science is really telling us.

  17. avatar Steve says:

    Hi Zoe, Thanks for the great review of this book, It is exactly what I’ve been searching for to allow me to more fully understand this whole farce. I purchased the book immediately and can’t wait to read it. I have been sparring with my GP who at this stage still goes with the Australian College of GP’s writings which of course recommend the use of Statins. I have already bought him a copy of another very good book, also called “The Great Cholesterol Con” but written by Anthony Colpo who is an Australian fitness trainer and a very thorough researcher.
    My GP promised me he would read it, he is actually quite open minded so I’m sure he will.
    This book will give me the info I need to further discuss all of this with him and make him understand why I will not take statins any more & also why I want my wife to get off them.


    • avatar Zoë says:

      Hi Steve – there’s another book called The Great Cholesterol Con by Dr Malcolm Kendrick – I much prefer that one. Funnier and less angry.
      Best wishes – Zoe

  18. avatar Neil says:

    Dear Zoe,
    Thanks for the reply and info’. I will certainly be sharing my statin experience with others.

  19. avatar Neil says:

    Was on Statins for 4 years. After approximately two years my legs became very weak with constant pins and needles and cramps. Some days I could hardly walk at all and I put this down to my degenerative spinal condition. In 2012, I began having abdominal discomfort, left side, under my ribs. The pain would come on after eating and could also be felt directly opposite in my back. I asked my doctor about the side effects of statins and he dismissed it and gave me a prescription for indigestion – My abdominal symptoms are like that of pancreatitis and I feel quite unwell. I have read that pancreatitis can be caused by statins – is this the case?
    I have felt so unwell this weekend I haven’t slept and will be making a GP’s appointment tomorrow.

    I stopped taking statins 5 months ago, my choice, and my leg weakness has improved. The pins and needles and abdominal pain persist.

    • avatar Zoë says:

      Hi Neil – thanks so much for sharing this. There are web sites around where non conflicted doctors are trying to collate information on statin side effects. If you come across one – do share this again!

      Dr Duane Graveline, former astronaut, describes his terrible damage on statins in his book Statin Damage Crisis. He also found that some problems went away when statins were stopped and some didn’t. Some damage is for life – and this post explains why.

      Very best wishes – Zoe

  20. avatar Janice says:

    I stopped taking atorvastatin about 10 days ago. I have been on them for a year. I have FH. My mother had a stroke and now has dementia. I started using plant sterols but after reading this info think that I shouldn’t use them either. I haven’t told my doctor, he is a very contentious doctor and obviously believed what he told me about my risk of stroke if I didn’t take them. I have been concerned that I was putting my health at risk not continuing with statins but had looked at debates on this drug and knew statins were big business, but still felt unsure. Your information has been a Godsend as I had not heard it explained this way, why LDL was in the bloodstream. I am going to print of this info and take it to my doctors as I have an appointment with him in a few weeks. Plus pass this onto to numerous relatives who are on statins. Thank you very much. Every blessing to you. Janice

  21. avatar Chris W says:

    Even after all this good work it seems that Nice will shortly be recommending Statins for wider use. A GP interviewed on Radio 4 as the ‘against’ voice said that patients frequnetly complained of muscle pain when taking statins which stopped when they stopped the drug. I’m not a medical person but isn’t the heart one of the most vital muscles in the body ?

    • avatar Zoë says:

      Hi Chris – yes – you’re spot on! Dr Malcolm Kendrick covers this in his Great Cholesterol Con. The CoQ10 impact on the heart is especially serious! What are we doing to our fellow humans?!
      They should put me or Malc on as the ‘against’ voice!
      Very best wishes – Zoe

      • avatar Chris says:

        Zoe, not sure If that was my post above, as Chris W…but it sounds like something I would say..my statin experience was a horror story. I was a 29 year old healthy and vibrant critical care RN since 1991. I was also like most other health care professionals a cholesterol choir boy. Singing the praises of Statins because, I was “educated” by pharma sales reps, who are paid very handsomely to sell drugs. 3.5 years after starting Lipitor, my world was rocked. I became very ill, hospitalized for 28 days at University of Wisconsin Madison hospital, brain biopsy revealed multiple holes(autophagic vacuoles) electron microscopy of the brain biopsy revealed Mitochondial DNA abnormalities consistent with Mitochondrial Encephalitis with lactic acidosis and stroke-like episodes aka MELAS. Muscle biopsy corroborated these findings. I have several dozen lesions on my brain, with these findings. Dr Beatrice Golomb MD, Phd of the UCSD statin effects study, which I was a participant in, has told me based on the results of that study, Lipitor was the likely causal contributor of the Holes in my brain, the Mitochondrial DNA mutations, and my peripheral neuropathy…which has left me disabled since Oct 2002. If you like I can share with you the dozens of articles and physician experts who also are well aware of these effects…email me if interested crandreww1999@yahoo.com

        • avatar Zoë Harcombe says:

          Hi Chris – thanks so much for sharing this – this is absolutely shocking, but not surprising knowing what statins do and the brain’s requirement for cholesterol. The only good news looks to have been coming across Dr Golomb.
          Can you sue in the land of lawyers?!
          Very best wishes – Zoe

          • avatar Chris says:

            Unfortunately Zoe, even in the land of lawyers, pharma companies have lots more $$$ to drag the litigation for years, Ive been told by a few attorneys, that these companies pay their legal teams, to drag the case out as long as possible…well until after I am dead. I am happy to settle for educating the public as much as I can, to stop listening to drug commercials, stop listening to ANY rants about cholesterol….its ALL CHECKBOOK SCIENCE, manipulated statistics, and ALL ABOUT THE ALMIGHTY $$…
            Whats even more scary that the plethora of problems statins cause, are the permanently disabling or even the deadly effects, such as ALS. My fathers best man, his best friend from childhood, died about 6 years ago after being diagnosed with ALS (Lou Gehrigs Disease) something I recall seeing as an RN, maybe once in my 12 year career. I asked my dad, if his friend was on a statin, and he later found out that yes he was. He had the same Rx happy doctor I had. I remember several years back when I began to research this scam, I met a young man, from Lake Tahoe, Doug Peterson, who was a victim of Statins, he has since passed away from this LIE! As a former RN, I have devoted much of my life now, to trying to educate the public, as to the very real, and potentially deadly effects of these POISONS! Id like to offer to share the clinical information with you and ALL of your followers, if I may. Please email me at crandreww1999@yahoo.com if you would like me to send you the information.

  22. avatar steve says:

    Dr. Yoseph mentioned several times that cholesterol is related to thyroxin – in a molecular way. Do you know what that is about?

  23. avatar Sherwood Smyth says:

    Huge Congratulations on your continuing excellent research, Zoe. The everyday ‘patient’ can feel frustrated by not being informed enough to convince the doctor that they have a valid point, though feeling pretty sure that in 10 years time their gut feeling will be received wisdom. So it’s great you are there, delving deep into the facts. So encouraging. Thank you.

    This morning I accompanied my 86 year old father to the doctor with my mother, and felt so patronised as I tried to explain why I don’t want him to take statins. My father has recently had aneurism, which has been fixed. He is mentally somewhat out to lunch, but in a happy way. Apart from that, he appears to have low risk factors: he hasn’t had a heart attack, or a stroke, he is very slim, he doesn’t have diabetes, he has low blood pressure, he doesn’t smoke, he has at least 5 portions of veg and fruit a day, he has oily fish and omega 3 supplements, he hardly drinks, and we are implementing an exercise programme. I want him to have a dignified, natural, end of life, not a pharmaceutical one, with toxic statins. I don’t expect or want him to live for ever, but the remaining years should be within our family’s ethos, of natural health. However, somehow, the doctor patronised me and dismissed my concerns about side effects, and numbers needed to treat, as ‘hype’ (as if I were a Daily Mail reader!). He managed to frighten my mother that without statins my father might die. I was so angry and helpless and upset. Altogether a disastrous morning!

    I now think perhaps I should let my mother give my father the statins for a week and write down all side effects day by day. If it is anything like the other grandparents’ experience, which was shocking, I would hope she will stop giving them to him under her own steam.

    What do you think of nicotinamide which the NICE Guideline recommends for those who don’t tolerate statins?

    • avatar Zoë says:

      Hi Sherwood – many thanks for your kind comments.

      Check the patient leaflet for statins (http://www.medicines.org.uk/emc/medicine/2498/PIL/) These have a caution for over 70 year olds. That’s the closest these companies will come to saying over 70s should NOT TAKE STATINS! (Not that any human should – but over 70s especially.) Low cholesterol = low longevity, as this post shows: http://www.zoeharcombe.com/2010/11/cholesterol-heart-disease-%E2%80%93-there-is-a-relationship-but-it%E2%80%99s-not-what-you-think/

      Perhaps mum should bang the doc over the head with the patient leaflet until he reads it. Bring on the lawsuits.

      As for nicotinamide – it’s not just statins that is the problem – it’s any attempt to impair the body’s ability to make the cholesterol that it needs, which is the problem. The older we get, the more cells die and struggle to repair – that’s where cholesterol can help. Even if nicotinamide did lower cholesterol (and this would suggest otherwise http://en.wikipedia.org/wiki/Nicotinamide) this would be a bad thing.

      Leave the body alone! It has incredibly few design faults. Making money out of stopping it doing what it was designed to do is about as evil as humans have ever been.

      Good luck to dad
      Very best wishes – Zoe
      p.s. statin damage is not always reversible, so I wouldn’t use dad as a guinea pig!

  24. avatar steve says:

    by the way i hear ubiquitone? is a good thing to take to improve coq10…how much a day is needed? and what are the good brands out there,cheers.

    • avatar Zoë says:

      Hi Steve – I’m so sorry to hear about your dad. There is no evidence for statins and strokes anyway – see Dr Malcolm Kendrick’s book – that’s one of the great contradictions in the whole cholesterol/statin scam – how would they help blood supply to the heart (heart attacks) if they don’t help blood supply to the brain (strokes). You almost certainly saved your dad – as he needed cholesterol to repair himself and you gave him a chance of his body having access to the cholesterol it needed to make.

      Even the patients leaflets say that over 70s shouldn’t be on statins. It’s not quite put like that, but it’s listed as a caution/contraindication as they know that cholesterol is even more important in old age – protecting dying cells and mind performance. I wonder if docs have ever read a patient leaflet?!

      CoQ10 is a valuable supplement. Some people take it to give their body more energy even if they are not feeling. Amounts can vary from 30mg to 200mg per day. I would take advice from someone in a health store e.g. Holland & Barrett. I don’t know any brands as I don’t take supplements. Someone may want to start low and build up or just go for a higher dose to see if there’s an immediate difference. I think the only harm going high would be on one’s purse!

      Good luck with dad – his body will start to heal now if it can make cholesterol unimpaired!
      Very best wishes – Zoe

  25. avatar steve says:

    Hi, my dad 84 year old was on statins for a few years and i managed to persuade him to come off them last summer because i could see his memory and muscle tissue rapidly decreasing..his urine was dark sometimes bloody..however his doc realised he wasnt getting repeat statin prescriptions and pressurised him to take them again despite having a cholesterol reading of 5.5.
    ON NOVEMBER 7TH he had a bleeding on the brain stroke,went into hospital and first thing they did was take him off Avorstatin..then they drugged him up with codiene,paracetomol and Amlodipine,fell out of his chair and smashed his nose needing stitches…then was virtually bed bound for 4 weeks occasionally hallucinating…managed to get him home after 4 weeks but very weak…its been 3 weeks out of hospital and now recovering well,walking unaided,eating well but memory still badly affected..off all drugs except prostrate drug finasteride although i’m convinced he dont need that and it was the statins affecting his prostrate and urinary tract.
    One of the biggest battles i had was fighting my close relatives who accused me of causing my dads stroke because i had taken him off statins last summer…never felt so alone in all my life so thank god there are sites like this..i’d of probably given up without them so thank you!

    • avatar Chris Wunsch says:

      Steve..I am so sorry to hear of your Statin dilemma! We have been so BRAINWASHED to believe Statins actually prevent stroke and heart disease, that we begin to believe it. The science simply is NOT there. NEVER has ANY statin study shown any benefit to a patient older than 65. http://chriskresser.com/the-truth-about-statin-drugs

      “Statins don’t increase survival in the elderly
      The only statin study dealing exclusively with seniors, the PROSPER trial, found that pravastatin did reduce the incidence of coronary mortality (death from heart disease). However, this decrease was almost entirely negated by a corresponding increase in cancer deaths. As a result, overall mortality between the pravastatin and placebo groups after 3.2 years was nearly identical.

      This is a highly significant finding since the rate of heart disease in 65-year old men is ten times higher than it is in 45-year old men. The vast majority of people who die from heart disease are over 65, and there is no evidence that statins are effective in this population.” Im sorry to hear your family is as brainwashed as the majority of the medical community…

  26. avatar Dr. Ellen K. Rudolph says:

    Zoe, this is an outstanding review, thank you for it. I have ordered the Yoseph book. However, I have been following the Cholesterol controversy for years and already know how terrible Statins are. The evidence has been out there — what in the world do we have to do to wake up physicians and even Congress? Hit them over the head with a 2×4? I have lost all
    respect for medicine, the AMA, the FDA, the USDA, etc. for the network of collusion they have perpetrated, all in the name of profit. To have all respected mdical journals in on the collusion makes it nearly impenetrable. Our ruling elites want to fix the health care system (i.e. via Obamacare) when they really need to clean the houses of their own troubled and corrupt buracracies from the top down. As for the United States Congress, are they sleeping or what??

    • avatar Zoë says:

      Hi Dr Ellen – you’ve made my day! For every individual who knows of this nonsense, ever doctor who knows this is worth many of us put together. You can make an even bigger difference by not perpetuating this crime. Thank you!
      Very best wishes – Zoe

  27. avatar Henrik says:

    Thanks, Zoe,

    Yes, I have been convinced for about a decade that the cholesterol scare was a myth. And I was really lucky to get a quadruple bypass without having a heart attack ever. I got severe angina, had an angiogram, and three different hospitals, actually in three different countries, gave me around 6 months to live, so surgery was inevitable. No fun, but the alternative was no fun either.

    I believe in what you preach, and believe in principle in the Paleo diet (a.k.a. the new evolution diet), although I try not to be fanatic about it. So now i just need to solve the “communication problem” about cholesterol with my highly regarded US-educated cardiologist. I am an expat living in the Philippines, which by the way, overall, has excellent doctors and hospitals that cost around 1/4 of the US rates. But almost all doctors are “mainstream” as to their background and education.

    Thanks, and please fight on! Why not team up with e.g. Arthur De Vany? Your basic messages are almost identical, although he is too much of an exercise freak for my taste :-).

  28. avatar Henrik says:

    I have had a heart bypass, which was naturally blamed on lifelong high cholesterol (around 300 since age 30+), and for the last 16 years I have been prescribed statins. I stopped on my own for two weeks just to check the effect, and the Cholesterol went back to around 300 again. My cardiologist ordered me back on Lipitor.

    So now the question: What else can I take to keep my cardiologist happy and keep the total cholesterol at present 200-level? Any doctor who will see a 300-level cholesterol will jump on me. I have a very experienced cardiologist, whom I would happily trust with doing a second bypass if and when needed. But if I do not take my statins he will effectively wash his hands of any responsibility. So what can I do to stay around 200 without statins? I already take 100mg Q10 since many years back, and of course un-coated 100mg Aspirin since 16 years back.

    • avatar Zoë says:

      Hi Henrik – what if your cardiologist thought that cholesterol is one of the most vital substances in the body – so vital that you die without it – and he knew the stuff in this blog post above and could not conceive of blocking your mevalonate pathway? What if he saw a cholesterol level of 300 (7.8 in UK speak) as not even that high (because it isn’t – it’s about where the average was before we mass medicated the ‘developed’ world). What if he appreciated that your body makes the cholesterol that it needs and that, if yours is higher than (say) mine, it is so for a reason? If you had a heart attack? (or did they just do a bypass because they measured arterial narrowing?) – this would have been the result of damage to the arterial wall. This post may help explain what might damage arteries and how narrowing can occur (http://www.zoeharcombe.com/the-knowledge/fat-does-not-clog-up-our-arteries/)

      You may have a hereditary condition but cholesterol is still not the problem – it’s part of your tool kit. If you have full blown Familial Hypercholesterolemia (and I would doubt this with cholesterol levels of 300) – this would indicate that Low Density Lipoproteins (LDL) were not able to get to all cells in the body (because FH indicates a malfunction of the LDL receptor) and this would harm cells – including cells in the arteries and the heart. Cholesterol is at best a marker – never a culprit.

      This may help too http://www.zoeharcombe.com/2010/11/cholesterol-heart-disease-%E2%80%93-there-is-a-relationship-but-it%E2%80%99s-not-what-you-think/

      Your problem is not cholesterol – your problem is having a cardiologist (who sounds better than many) who won’t do the things you may want/need him to do if you don’t do the one thing that he has been led to believe you should do. No doc would ever get a statin to pass my lips so I’ll be in big trouble if I develop heart disease! All the more reason to avoid sugar and manage stress :-)

      I really feel for you – good luck in educating the people who need to know
      Very best wishes – Zoe

    • avatar Mike Rohrbeck says:

      Give up carbs, eat more healthy fats and forget about your cholesterol. Your other vitals will all improve.

  29. avatar khurram says:

    lucky that i read this article thanks.can you comment on the fact that most of the doctors prescribe these drugs but they donot inform their patients about the bad effects

  30. avatar Max Wyght says:

    So basically, instead of trying to block the melavonate pathway, we should look for a way to expand it?

    Because this is how I understood the article.

    In other words, I now believe the Illuminati are real, and that they are trying to decrease the global population, all because of this article…

    And this is coming from a guy who considered Illuminati believers to be total whackos and idiots…

  31. avatar Jeff Cable says:

    Hi Zoe.
    What an excellent blog! I would like your permission to add a link address to my e-petition rubric so that sufferers with statin-mediated side effects will have access to this excellent information.


    Kind regards,

  32. avatar Claire Birtles says:

    I am a practice nurse in the Uk and am expected to trot out the low fat fallacy to everyone I meet. Needless to say I don,t. But what amazes me is that doctors, supposedly highly educated and well trained, (plus presumably well paid) don’t have this anatomy and physiology information at their fingertips. When I take my car to be fixed I trust the mechanic knows exactly how the engine works!

    • avatar Zoë says:

      Hi Claire – how lovely to hear there is someone like you out there – if only there were more :-)
      Very best wishes – Zoe

  33. avatar Koen says:

    I stopped taking simvastatine a couple of months ago, since I became aware of the negative “side effects”. Statines are POISON! Indeed, doctors and hospitals don’t know what they are doing. I suffered a mild stroke 2 years ago, which affected the left half of my entire body (reduced strength and sensitivity). During the years before my stroke, I had tias almost everyday. The hospital concluded I had a leaking artery (hemorraghic), but after my stroke MRI scans showed this was not the case, my stroke was ischemic, and so where the tias. In other words, the hospital robbed me from the change to PREVENT my stroke by NOT prescribing medicin in order to solve the blockage in my brain artery. Later on they prescribed SIMVASTATINE. After the impact of the stroke diminished during two years, I stayed very tired and had muscle cramps almost daily. I also noticed reduced strength in my entire body after two years of taking simvastatine. I am slowly recovering now, no more daily cramps! Still taking blood thinner carbasalate calcium.

  34. avatar George @ the High Fat hep C Diet says:

    it’s entirely possible that there is a medical use for statins, but using LDL levels to find it is obviously flawed because these can be indicative of many different things.

    Another isoprenoid that’s depleted by statins is endogenous vitamin K2

  35. avatar Maarit says:

    My husband and I live now in Finland and here things are exactly the same as in UK. My husband has inhereditary kidney disease and his last blood test showed that his creatin (spelling?) levels were high and so were his cholesterol levels. He has now received a letter from a doctor (who hasn’t even seen my husband) that he should start taking statins. What about his kidneys? Are they not worried? I am! His kidney problem is already causing him physical discomfort in his legs so I would think taking Statins would make that even worse. I have ordered the book in this review and also two books by Uffe Ravnskov. But it seems that we are fighting a losing battle here.

  36. avatar Magnus says:

    @Ulf… Ingen kan tvinga dig att ta någon form av medicin. Vill du inte ta dem ska du inte göra det. Biverkningarna av dem kan potentiellt bli riktigt allvarliga och nyttan av dem är… tveksam.

  37. avatar Ulf Gullberg says:

    Man har ju haft sina funderingar jag äter statiner 40 mg lipitor ,har ätit statiner i 20 år och är 58 år . Jag gjorde en byepass 2006 hade då 4 förträngningar som man hittade vid ett arbetsprov , det betyder att jag har aldrig haft en infarkt, men är väldigt överviktig. Jag är nykter alkoholist sedan 2006 , slutade även samtidigt att röka och snusa, men gick sakta men säkert upp 30 kg, till 125 kg , har nu med LCHF gått ner och upp 20 kg 2gånger på 3 år. Jag väger nu 115 kg och är på väg neråt . Jag har sådan värk i mina ben dygnet runt och tror att det är från statinerna , skulle vilja sluta med dessa piller . Det hör till saken att min mamma säger att hon har FH , eftersom hennes mamma ( min mormor )hade FH . Jag har ett par morbröder som alla dog i hjärtinfarkt innan de fyllde 60 år och min mamma har haft 2 infarkter och gjort en byepass. Jag hade även en syster som var väldigt överviktig ( 135 kg ) hon fick en infarkt och dog i sömnen när hon var 48 år.
    Min doktor säger att jag ska äta dessa statiner men jag vill inte .

  38. avatar Allan Folz says:

    Wow. I’ve seen it suggested heart disease could be the result of a newly mutated infectious agent. It was largely unknown until the early 20th century, became hugely wide-spread with a high morbidity, and now seems to have run its course. Given cervical cancer is now recognized to be the result of a viral infection, it’s a plausible theory.

    As I understand it, the one group for which statins have been shown to be efficacious in controlled trials is middle-aged men with a prior history of myocardial infraction, for instance commenter Benny above.

    If we assume myocardial infraction is test positive for “cardiac infection,” and statins are powerful antibiotics, then yes, statins should work very well for that population. Very interesting! Of course the side-effects make them some very strong medicine, and taking them prophylactically is absolutely malpractice.

    • avatar Zoë says:

      Hi Allan – one view of the one small part of the population where statins seem to have ‘an effect’ is that they have anti-inflammatory properties. Indeed drug cos have started talking about statins and arthritis, so I suspect they know a plausible mechanism. There are other ways of dealing with inflammation (which is a marker as well as a healing process as well as a problem) e.g. aspirin/ibuprofen – but these are not lucrative. If statins do impact inflammation then the cholesterol lowering is a serious side effect.
      Sounds like we’re kindred spirits on this one!
      Very best wishes – Zoe

  39. avatar Werner says:

    Hi Zoe

    I suffer from FH, but not the extreme version. Can you clarify if your article/ the book is saying that no-one with FH would benefit from statins, or only those with the extreme version.


    • avatar Zoë says:

      Hi Werner – I know my view and I suspect the Yosephs are the same – is that a statin would never pass my lips. Professor Tim Noakes puts it as – I would never prescribe a statin to a loved one. I cannot see how they can ever do anything other than serious harm. Making cholesterol is a life vital human pathway and we mess with it at our peril. FH is a condition of LDL receptor impairment – whether ‘extreme’ or partial – it still means that the main issue is that every cell in the body can’t receive the LDL that it needs to a greater or lesser extent. How can stopping cells from making their own cholesterol then help?! If we saw the high LDL in the blood stream as a marker and not a condition or a cause of anything – we would see FH in a very different light.

      The Uffe Ravnskov “Ignore the Awkward” book has some great evidence and references on studies of FH people and longevity – you might be pleasantly surprised!
      Very best wishes – Zoe

  40. avatar TeeDee says:

    Hi Zoe: I couldn’t even think of writing a comment after first reading your review of this book. I was totally blown away and could only think: “Wow!” And now, in light of the fact that all of the excellent comments have expressed what I would have, I can only say thank you so very much for this amazing review. Also, like you, I know that I will never, ever allow a statin to pass my lips (or the lips of my loved ones if I have anything to do with it!). Keep up the good fight and thanks again!

  41. avatar Deborah Dunkerton says:

    it took just three years for statins to reduce my mothers brain to mush – she now lives in a nursing home unable to speak or understand language.
    There were plenty of warning signs, she became forgetful, her muscles cramped and ached, but the doctors fixed that with more drugs and pain killers. finally she started to have seizures and i stepped in and reviewed all her drugs (12 in all) via google. What i discovered horrified me, she was on 60mg of lipitor plus three other drugs that lowered blood pressure, her brain was essentially being starved of oxygen and nourishment.
    but it was too late, the damage was done. Now i will personally make it my life mission to warn other people about the dangers of statin drugs.

  42. avatar Jacqui says:

    Excellent write-up; thanks. I knew statins blocked Q10, but didn’t know the rest of it. I’m looking forward (in a stunned and shocked way) to now reading the book. I keep banging on to people about not taking statins; now I can be better informed in my arguments.

  43. avatar Graham says:

    Thank you for taking the time to write such an informative article. It would be really interesting to know if anyone who was in this conspiracy does, or if any of their family members have ever taking these drugs.

  44. avatar jimmy says:

    These researchers synthesized the statin trials which resulted in these numbers:

    After Statins taken for 5 years
    1 in 83 were helped (life saved)
    1 in 39 were helped (preventing non-fatal heart attack)
    1 in 125 were helped (preventing stroke)

    1 in 167 were harmed (develop diabetes*)
    1 in 10 were harmed (muscle damage)

    After Statins taken for 5 years
    None were helped (life saved)
    1 in 60 were helped (preventing heart attack)
    1 in 268 were helped (preventing stroke)

    1 in 67 were harmed (develop diabetes*)
    1 in 10 were harmed (muscle damage)


    So much spinning of humanities’ wheels distracting from finding viable therapies…

  45. avatar Ann Shirley says:

    Great article! It’s amazing how many people take statin drugs and are oblivious to its harmful effects. What’s even more sad is that often times the statins are over-prescribed and patients could find a much safer alternative. I have been taking coq10 supplements instead of statin drugs and have noticed a great difference in my overall health for the better.

  46. avatar Jessica says:

    And how disappointed I was to hear even Michael Mosly state that he had decided to take statins
    himself afterall and in spite of all the conflicting information. True it was on his personal
    note, yet many people will only have heard him condoning the stuff in last week`s BBC programme
    Trust me I am a doctor. Dear Zoe, thank you so much for your work. I prefer to trust you more.

  47. avatar benny says:

    I had my triple heart by-pass cause my arteries were so plugged. I have crestor ( statins drug) in the medicine cabinet. We were told taking Crestor was the fix, now learn we were being lied to. What is the fix So what is one to do? What is the best path.

  48. avatar Jan says:

    I am not a medical person just someone who does her best to live a healthy lifestyle. The more I read about statins the more I feel I wouldn’t want to take them. Many friends have been prescribed and have dutifully followed their Doctors advice. But if “Cholesterol is utterly life vital” are we really doing the right thing in taking statins?

    All the best Jan

  49. avatar Eric says:

    Thank you so much for bringing this book to my attention. I’m appalled. Recently my doctor said my cholesterol was high but she wasn’t going to prescribe anything just yet. I told her it was just as well, as I wouldn’t take anything anyway.

    I was wondering if you thought a layman such as myself could adequately understand this book, seeing as how it is aimed at medical professionals and lawyers. I noticed they have a “Made easier” version of the book for layman. http://www.amazon.co.uk/Serial-Killers-Statin-Really-Cholesterol/dp/0988820633/.

    I have read Good Calories/Bad Calories twice, and found some of it tough going, but mostly managed it fine.

    Thank you again.

    • avatar Zoë says:

      Hi Eric – thank you SO much for sharing this second link. I’ll add it in to the main article – whichever one people get, it could help enormously.
      There’s also a shorter/simpler partner to Good Calories/Bad Calories also – http://www.amazon.co.uk/Why-We-Get-Fat-Vintage/dp/0307474259

      I think we all find these tough going on first read – not least because they turn your belief system upside down. I remember when I first read Dr Malcolm Kendrick’s brilliant Great Cholesterol Con and I hadn’t even thought that there can’t be 2 versions of one chemical formula – this whole daft notion of good and bad cholesterol. You bang yourself on the head and wonder why you didn’t question it – but at least the smart people are reading and questioning now

      Very best wishes – Zoe

  50. avatar Kate Holland says:

    This is one of the scariest things I’ve read! The perpetrators of the statin scam should be prosecuted, or just put in front of the firing squad. They are killing millions. I stopped taking stations about a year ago, hope my body has healed! I had only been taking them for a few years. Now I’m concerned for my husband, he was taking them way before me, and takes them still. (A retired nurse) I’m doing my best to re educate him.

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